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Prescription onlyFDA-approved
Progesterone
Prescription — nightly oral capsule
The body-identical progesterone prescribed alongside estrogen for anyone with a uterus — and often the quiet hero for sleep.
FDA-approved micronized progesterone — the body-identical form, not a synthetic progestin.
Adding to your plan doesn't order anything and doesn't charge you — it tells the provider what you're hoping to discuss.
About 5 minutes. A licensed provider reviews your health and prescribes progesterone only if it's right for you — there is no checkout here, and that's deliberate.
How it works
What it actually does
Estrogen taken alone stimulates the uterine lining, and over time that unopposed stimulation raises endometrial cancer risk. Progesterone is what opposes it — keeping the lining thin, which is why it's non-negotiable alongside estradiol for anyone with a uterus. Micronized progesterone is the body-identical form; taken at night, its metabolites act on the same receptors as the brain's own calming signals, which is why drowsiness is listed as a side effect and experienced as a feature.
See the full mechanism, step by stepA provider may consider it if
- You have a uterus and are starting or on estrogen therapy — this is the partner medication
- Sleep disruption is among your symptoms — nightly dosing works with that
- You want the body-identical form and a provider who explains the difference
It won't be prescribed if
- A history of breast cancer or hormone-dependent cancer, without specialist care
- Significant liver disease
- A peanut allergy, for formulations that use peanut oil — flag it and the pharmacy works around it
These are the same checks the visit runs. If one applies, the visit will tell you plainly rather than take your money.
What to expect
Realistically, month by month
Weeks 1–2
Drowsiness after the nightly dose is expected — take it at bedtime and let it work with you.
Ongoing
Reviewed alongside your estrogen at every check-in, as one plan rather than two prescriptions.
Safety, stated up front
Side effects, before you decide
Drowsiness and dizziness after dosing are the common ones — nightly timing exists for a reason. Breast tenderness and spotting can occur early. Serious risks track those of combined hormone therapy and are part of the same honest conversation.
- FDA prescribing information: micronized progesterone capsules
Complete safety information is provided during your visit and with every prescription. This page is a summary, not a substitute for your provider's advice.
Questions
Asked honestly, answered honestly
Why do I need this if estrogen is what treats the symptoms?
Because estrogen alone stimulates the uterine lining and raises endometrial cancer risk over time. Progesterone protects it. If you've had a hysterectomy, that calculus changes — which is exactly the kind of thing your provider sorts out.
Also for women's health
See whether progesterone is right for you
Five minutes of questions, reviewed by a licensed provider. Treatment only if it's appropriate — and a straight answer either way.