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Compounded — not FDA-approvedPrescription only
Compounded B12 / Glutathione / NAD+ / Sermorelin Bundle
Compounded — injection bundle, four vials
Four compounded injectables — vitamin B12, glutathione, NAD+ and sermorelin — supplied together for a provider-led longevity plan. Each has its own regulatory footing and its own limits, described plainly here.
This bundle is compounded for you by a licensed 503A pharmacy and is not FDA-approved. Each component stands on a different footing: vitamin B12 is the active ingredient of a manufacturer's FDA-approved cyanocobalamin injection, or methylcobalamin, which sits on FDA's Category 1 list; glutathione and NAD+ are on FDA's list of bulk substances under evaluation for compounding (Category 1); sermorelin is the active ingredient of Geref, a product discontinued in 2008 for reasons unrelated to safety, whose compounding standing is under FDA review. Human outcome data for the combination is limited.
From$379/mo$32 consultation included, not refunded · medication and shipping if prescribed
Choose your plan
4-week supply
Price
$379for a 4-week supply, if prescribed
Includes your $32 provider consultation (non-refundable). If your provider decides treatment isn’t appropriate, the medication portion is refunded automatically.
- Your provider confirms the dose. If they start you on a lower step, we refund the difference; if they choose a higher one within the same plan, the price you paid stands.
Adding to cart books a provider visit. You pay the shown total; the provider decides; the medication portion comes back automatically if they say no.
Questions
Will I definitely be prescribed this?
No — a consultation does not guarantee a prescription, and with four components a provider may prescribe some, all or none. Sermorelin in particular needs a patient-specific reason attested by the prescriber, and B12 injections are approved for deficiency, so injecting B12 without one is an off-label judgment your provider makes. If any part isn't appropriate for you, we'll tell you why and the medication portion of your payment is refunded; the consultation fee is not.
Can I get just one of these?
Yes. NAD+, glutathione and sermorelin each have their own page and their own supply on this account. The bundle exists for people whose provider has already decided on all four; it is not a discount on judgment.
Do I need to be B12-deficient?
The approved use of injectable B12 is deficiency caused by malabsorption — pernicious anaemia, gut surgery and the like. Using it without a measured deficiency is off-label, and your provider may ask for a blood level first or decide it is not warranted. If you have been told you have early Leber's disease, say so: cyanocobalamin is contraindicated there.
How it works
This is four separate injectables in one supply, and each does something different. Vitamin B12 is the cofactor for two enzymes your body cannot run without — one that recycles folate for DNA synthesis and red-cell formation, one that keeps nerve myelin healthy; an injection bypasses the gut, which is why it is the treatment for deficiency caused by malabsorption. Glutathione is the cell's main home-made antioxidant and the molecule the liver uses to tag toxins for excretion. NAD+ is the coenzyme at the centre of converting food into cellular energy and a substrate for DNA-repair enzymes. Sermorelin is a fragment of growth-hormone-releasing hormone that prompts your own pituitary to release growth hormone in its own rhythm. Bundling them does not make any one of them work differently: it is a supply convenience, and your provider decides whether each belongs in your plan at all. There is no published trial of the four together, and the outcome data for each on its own is limited — the mechanisms are what we can describe.
The full mechanismA provider may consider it if
- You and your provider have agreed on each of the four separately, not on the bundle as a package deal
- You're comfortable with several self-injections a week after instruction, on the schedule your provider sets
- Recovery, sleep and energy are the things you're working on, and you accept that the evidence is early
It won’t be prescribed if
- Active cancer, or a history of it, without your oncologist involved — sermorelin raises growth-hormone signalling, and this is a hard stop
- Early Leber's disease (hereditary optic neuropathy) — the cyanocobalamin label reports severe optic atrophy, and it is a contraindication
- A known sensitivity to cobalt or to vitamin B12, or a previous reaction to any compounded injection
- Pregnancy or breastfeeding, without provider review
- Untreated thyroid or adrenal conditions, which blunt the axis sermorelin works through
- Asthma, without provider review — inhaled glutathione has triggered bronchospasm, and providers extend that caution to injections
These are the same checks your provider runs in the visit. If one applies, they will tell you plainly — and the medication portion of what you paid comes back automatically.
What to expect
Week 1
Instruction on which vial is which, how often each is injected and how to store them. Injection-site soreness is the common early experience across all four.
Weeks 2–6
Sleep quality is typically the first thing people notice with sermorelin. Flushing or nausea after NAD+ or glutathione usually means the dose went in too fast. Fever or chills within minutes of any dose are not normal — stop and contact the care team the same day.
Ongoing
Reviewed at check-ins like any prescription — and reviewed per component: your provider may keep some and drop others, which is the point of prescribing them one at a time.
Safety
Side effects, before you decide
Injection-site pain or redness is common with all four. B12 injections can cause itching, a transient rash, mild diarrhoea and, rarely, a serious allergic reaction; the cyanocobalamin label also warns of low potassium when a severe anaemia is treated intensively. Glutathione and NAD+ can cause flushing, nausea, cramps and headache, generally mild, and both carry the contamination risk of any compounded injectable, which is why the pharmacy's endotoxin testing matters. Sermorelin can cause flushing, headache and dizziness, and because it raises growth-hormone signalling, cancer history is screened before prescribing. Long-term safety of the combination has not been studied.
- Cyanocobalamin injection USP prescribing information, DailyMed, revised 04/2025 — indications, contraindications, warnings and adverse reactions
- Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Molecular Aspects of Medicine, 2009;30:1–12
- Covarrubias et al., Nature Reviews Molecular Cell Biology, 2021 — NAD+ metabolism and aging review
- Walker RF. Sermorelin: a better approach to management of adult-onset growth hormone insufficiency? Clinical Interventions in Aging, 2006;1(4):307–308 — a commentary on the mechanism, not a trial
Complete safety information is provided during your visit and with every prescription. This page is a summary, not a substitute for your provider's advice.
Also for longevity
Compounded NAD+From$229/mo$32 consultation included, not refunded · medication and shipping if prescribed
Compounded SermorelinFrom$209/mo$32 consultation included, not refunded · medication and shipping if prescribed
Compounded Low-Dose NaltrexoneFrom$169/mo$32 consultation included, not refunded · medication and shipping if prescribed
Compounded GlutathioneFrom$209/mo$32 consultation included, not refunded · medication and shipping if prescribed
Compounded TesamorelinFrom$229/mo$32 consultation included, not refunded · medication and shipping if prescribed
Compounded Methylene BlueFrom$129/mo$32 consultation included, not refunded · medication and shipping if prescribed
See whether compounded b12 / glutathione / nad+ / sermorelin bundle is right for you.
A licensed provider reviews your visit and decides. You receive medication only if prescribed, and that portion of your payment is refunded automatically if they say no.