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Compounded Low-Dose Naltrexone — illustrative product photograph
Compounded — not FDA-approved · off-label usePrescription only

Compounded Low-Dose Naltrexone

Compounded — daily low-dose oral

A decades-old medication at one-tenth its approved dose, prescribed off-label for inflammation-linked symptoms and recovery.

$169 4-week supply $32 consultation included, not refunded · medication and shipping if prescribed

Important safety information

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4-week supply

Price

$169 for a 4-week supply, if prescribed

Includes your $32 provider consultation (non-refundable). If your provider decides treatment isn’t appropriate, the medication portion is refunded automatically.

  • Not available in California, Louisiana or South Carolina.

Paying books a visit with a licensed provider, who decides whether to prescribe and which strength is appropriate. If nothing is prescribed, the medication portion is refunded automatically; a higher strength costs more only if you approve that charge.

How it works

Naltrexone is FDA-approved at 50mg for opioid and alcohol dependence. The 1.5–4.5mg dose is an off-label use, compounded because no manufacturer makes tablets that small.

At 50mg, naltrexone blocks opioid receptors outright. At 1.5–4.5mg taken at night, it blocks them only briefly — and the body's response to that short blockade is a rebound increase in its own endorphins, plus a quieting effect on glial cells, the immune cells of the nervous system. That second mechanism is why it's studied in inflammation-linked conditions. The evidence base is a collection of small trials — promising, honest-sized, and your provider will characterize it that way.

The full mechanism

Who it’s for

A provider may consider it when

  • Inflammation-linked complaints your provider thinks fit the mechanism
  • You want a low-cost, low-risk addition before exotic ones
  • You're not taking opioids — including occasional use

Reasons it may not be prescribed

  • Anyone using opioid medication, including as-needed painkillers — the interaction defeats both drugs and can precipitate withdrawal
  • Acute liver failure or active hepatitis, without specialist review
  • Pregnancy or breastfeeding, without provider review

These are the same checks your provider runs in the visit. If one applies, they will tell you plainly — and the medication portion of what you paid comes back automatically.

What to expect

  1. Weeks 1–2

    Vivid dreams are the classic early effect and usually settle. Some providers start at 1.5mg for exactly this reason.

  2. Months 1–3

    Where symptom change is honestly assessed. Response varies more than with mainstream drugs, and your provider will treat that as data, not failure.

Important safety information

Vivid dreams, sleep disturbance early on, headache and nausea are the reported ones, generally mild at this dose. The serious interactions are with opioids — which is why the medication review in your intake is not a formality.

  • Younger et al., Clinical Rheumatology, 2014 — review of low-dose naltrexone mechanisms and trials

Complete safety information is provided during your visit and with every prescription. This page is a summary, not a substitute for your provider's advice.

Questions

Will I definitely be prescribed this?

No — a consultation does not guarantee a prescription. A licensed provider reviews your health history, your liver and every medication you take — opioids of any kind rule it out — and prescribes only if it's appropriate for you. If it isn't, we'll tell you why and the medication portion of your payment is refunded; the consultation fee is not.

Why does it need a compounding pharmacy?

Because no manufacturer makes a 4.5mg tablet — the approved product is 50mg. A compounding pharmacy prepares the low-dose capsules to the strength your provider prescribes.

Also for longevity

$32 consultation included, not refunded · medication and shipping if prescribed

$32 consultation included, not refunded

See whether Compounded Low-Dose Naltrexone is right for you.

A licensed provider reviews your visit and decides. You receive medication only if prescribed, and that portion of your payment is refunded automatically if they say no.

Choose your option